Efficacy and safety of lumbrokinase plus aspirin versus aspirin alone for acute ischemic stroke (LUCENT): study protocol for a multicenter randomized controlled trial ~ May 15, 2023



Lumbrokinase has been widely used for patients with acute ischemic stroke (AIS) in China; however, because rigorously designed studies are lacking, safety and efficacy of lumbrokinase in the treatment of acute ischemic stroke remains largely unknown. In this multicenter, randomized, and controlled trial, we aim to compare lumbrokinase plus aspirin versus aspirin alone in patients with acute ischemic stroke.

Stroke is a major cause of mortality and morbidity worldwide. Each year, 15 million people are diagnosed with stroke globally; of them, 5 million suffer from death and another 5 million become permanently disabled [1]. Ischemic stroke accounts for approximately 80 to 87% of all strokes [2]. Among patients with a minor ischemic stroke or a transient ischemic attack (TIA), 3 to 15% will get ischemic stroke 90 days later [3]. As a traditional and the most widely used antiplatelet therapy, aspirin reduces the risk of early recurrent ischemic stroke and improves long-term outcomes without a risk of hemorrhagic complications. However, breakthrough ischemic strokes are not uncommon in patients who are already taking aspirin monotherapy and an addition of a second antiplatelet therapy like clopidogrel significantly increases the risk of bleeding.

What Does This Mean?

How can the “common man” prevent strokes (brain bleeding) from happening? One method has been to include aspirin (a lower-dose “baby aspirin) as a preventative measure against both strokes and heart attacks. Some physicians also want to add another (usually prescribed) anti-coagulant, yet this addition adds to prescriptions costs, as well as amping up irregular bleeding!

Now, studies are being performed on a non-prescription, “natural” blood thinner, lumbrokinase (aka Lumbrokinase vs Nattokinase vs Serrapeptase) to enhance the ability of the human body to control the incrediably complex bleeding/clotting cascade in the human body.

Will use of lumbrokinase replace the ever-so-popular pharma drug, Eliquis? Good question! One important point to remember…do your own research, take this with the same precautions as a “prescribed” blood thinner, increasing your chances of BEing in…

Quantum Joy!


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.